A Japanese man with severe anemia — a condition marked by too few red blood cells in the body — following a case of COVID-19 tested positive for cold agglutinins and cryoglobulins, two types of antibodies that become reactive in the cold, according to a new report. Cold agglutinins are…

Among people with cold agglutinin disease (CAD), more than half were found to have a related autoimmune disorder called cryoglobulinemia, which affected symptom presentation but did not appear to affect survival. That’s according to a small study in which 59% of CAD patients tested positive for cryoglobulins, the…

Specially designed miniaturized antibodies, or nanobodies, reduced blood cell destruction in a new mouse model of a disease similar to cold agglutinin disease (CAD), a study showed. These findings suggest that the nanobodies, designed to suppress the complement cascade by blocking the complement component 2 (C2) protein, could…

A 71-year-old woman with primary cold agglutinin disease (CAD) was successfully treated with the glucocorticoid prednisone, a case study reported. Its scientists noted that primary CAD typically does not respond to glucocorticoids, but in particular instances like this case, it can. The study, “A Case of Idiopathic Cold…

A type of protein modification called glycosylation is associated with higher levels of disease-causing antibodies in cold agglutinin disease (CAD), new research suggests. The findings highlight the role that antibody modifications play in antibody-driven diseases like CAD, researchers said. The study, “In from the cold: M‐protein…

Cold agglutinin disease can lead to serious complications during pregnancy, according to a case study of two women with autoimmune hemolytic anemia (AIHA). The study’s researchers emphasized the importance of a complete molecular diagnosis of AIHA to estimate maternal and fetal risks, and to establish…