I sleepily scratched a bug bite on my arm. It felt a bit different from a mosquito bite — perhaps it was from a red ant or a spider. I rolled over and went back to sleep. That afternoon there was a sore the diameter of a pencil on my…
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Zydus Lifesciences’ desidustat eases the anemia and red blood cell destruction that mark autoimmune hemolytic anemia, or AIHA, a group of autoimmune conditions that includes cold agglutinin disease (CAD), a study in a mouse model has found. The oral therapy was shown to stimulate red blood cell production…
“It rained and it rained and it rained.” That’s the beginning of the ninth chapter of A.A. Milne’s “The House at Pooh Corner.” Piglet tells himself that he’d never seen so much rain in his life. I felt a lot like Piglet when I went home in Sentani, Papua, Indonesia,…
Parsaclisib, an experimental oral therapy from Incyte, safely and effectively increased levels of hemoglobin in about half of people with cold agglutinin disease (CAD) in a small Phase 2 clinical trial, a study shows. Data from the study (NCT03538041), which included people with other forms of autoimmune…
Waking groggily, the patient stretched his arm out from under the covers. Hitting the “stop” button on his phone, he groaned. It was time to eat and take his next dose of anti-nausea medicine. After giving it 20 minutes to start working, he took his malaria medicine. To get the…
Cold agglutinin disease (CAD) is a rare disorder in which the immune system mistakenly attacks red blood cells, resulting in anemia.
CAD is characterized by autoantibodies, called cold agglutinins, binding to and activating the destruction of red blood cells when exposed to cold temperatures.
Symptoms of CAD include fatigue, Raynaud’s syndrome, joint pain, jaundice or skin discoloration, and heart problems. These symptoms can worsen with more cold exposure.
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