I started trembling when I saw the tribal warrior approach with a wicked long spear. Yikes! How can I get out of here? I looked around the room and realized there was no escape. The man and his henchman were in the room with me, while reinforcements stood just outside…
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Treatment with rituximab — commonly used off-label for cold agglutinin disease (CAD) — was reported to successfully resolve a serious case of CAD secondary to an Epstein-Barr virus (EBV) infection and potential contraceptive pill toxicity in a young woman in Europe. The woman had developed severe jaundice and liver…
It was totally dark, and I couldn’t remember where I was. I was nice and comfortable in this soft bed with its squishy pillows. I blinked my eyes and remembered: I was traveling back to the U.S. to see my dermatologist. I was in the Ambassador Hotel at Singapore’s Changi…
Establishing a diagnosis of autoimmune hemolytic anemia (AIHA), a group of conditions including cold agglutinin disease (CAD), is sometimes difficult, due to the high variability in signs and symptoms and the possibility of a secondary cause, a review study showed. “Additionally, therapy is poorly evidence-based and mainly funded on…
I sleepily scratched a bug bite on my arm. It felt a bit different from a mosquito bite — perhaps it was from a red ant or a spider. I rolled over and went back to sleep. That afternoon there was a sore the diameter of a pencil on my…
Cold agglutinin disease (CAD) is a rare disorder in which the immune system mistakenly attacks red blood cells, resulting in anemia.
CAD is characterized by autoantibodies, called cold agglutinins, binding to and activating the destruction of red blood cells when exposed to cold temperatures.
Symptoms of CAD include fatigue, Raynaud’s syndrome, joint pain, jaundice or skin discoloration, and heart problems. These symptoms can worsen with more cold exposure.
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