The oral medication iptacopan — approved for certain blood and complement-related conditions — helped alleviate anemia in most people with cold agglutinin disease (CAD) in a small Phase 2 clinical trial, according to study. The complement cascade is a component of the immune system that contributes to the hemolysis,…
Discussion
As soon as I felt the tug on my computer cord, I knew the glass would fall. My husband, Mike, and I were getting ready to head to Jayapura, Indonesia, from our home in Sentani, a distance of only 22 miles, for an appointment at the immigration office, but it…
Enjaymo (sutimlimab-jome) remains safe to use over the long term, according to new real-world data from adults with primary or secondary cold agglutinin disease (CAD) who have been taking the approved medication for an average of more than two years. The data come from CADENCE (NCT05791708), an…
Discussion
My husband, Mike, had obviously been thinking about my upcoming medical travel. “Do you have a coat to wear when you get off the plane in Atlanta?” he asked. At present, I have difficulty walking through my house. How was I going to make the long journey from the tropics…
A bacterial lung infection caused by Mycoplasma pneumoniae— a very small cell bacterium known as M. pneumoniae for short — triggered cold agglutinin disease (CAD) and severe blood clotting in a man in his late 50s, according to a case report from the U.S. The man recovered after treatment…
Cold agglutinin disease (CAD) is a rare disorder in which the immune system mistakenly attacks red blood cells, resulting in anemia.
CAD is characterized by autoantibodies, called cold agglutinins, binding to and activating the destruction of red blood cells when exposed to cold temperatures.
Symptoms of CAD include fatigue, Raynaud’s syndrome, joint pain, jaundice or skin discoloration, and heart problems. These symptoms can worsen with more cold exposure.
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