“Easy, easy,” I said in my most reassuring voice. “It’s very easy to get to my house. There are only two turns.” Despite that, the courier from the shipping company was telling me that I lived too far out in the jungle for him to possibly find my house and…
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The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale, a widely used questionnaire to assess fatigue, is reliable, valid, and responsive to changes in the severity of cold agglutinin disease (CAD), according to a study. The findings relied on CAD patients’ impressions of the FACIT-Fatigue scale and data from…
Inhaling deeply, I took in the clearness of the June morning. The zoysia grass in our front yard was thick and green and luscious, like a deep-pile carpet. Off in the distance, I could hear a hawk squawking at its mate. Some magnolia blossoms were on low-hanging branches nearby, and…
Annexon Biosciences’ new tablet formulation of its experimental therapy ANX1502 reduced key clinical and biomarker measures in the three cold agglutinin disease (CAD) patients so far enrolled in a proof-of-concept clinical trial. “In patients treated with the oral small molecule ANX1502, we are encouraged by the changes in…
Looking out my window as I start to write this column, I see what appears to be a sunny day. But there’s a cloud covering the top part of the mountain, so it may not be sunny for long. My pets, Pokey and Ginger, are sound asleep. Should I get…
Cold agglutinin disease (CAD) is a rare disorder in which the immune system mistakenly attacks red blood cells, resulting in anemia.
CAD is characterized by autoantibodies, called cold agglutinins, binding to and activating the destruction of red blood cells when exposed to cold temperatures.
Symptoms of CAD include fatigue, Raynaud’s syndrome, joint pain, jaundice or skin discoloration, and heart problems. These symptoms can worsen with more cold exposure.
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