Marisa Wexler, MS, senior science writer —

Initial results from a planned proof-of-concept clinical trial testing Annexon Biosciences’ treatment candidate ANX1502 in people with cold agglutinin disease (CAD) are expected in the second half of the year. “We anticipate clinical proof-of-concept data from our novel oral inhibitor ANX1502 later in the year,” Douglas Love, president…

Apellis Pharmaceuticals and Swedish Orphan Biovitrum (Sobi) have stopped the clinical development of the experimental therapy pegcetacoplan for cold agglutinin disease (CAD). The decision, which includes discontinuing a Phase 3 clinical trial of the therapy in adults, was based on a realignment of the companies’ priorities in…

Certain variations in genes that encode cytokines — signaling molecules involved in immune responses — may predispose people toward the development of cold agglutinin disease (CAD), a new study suggests. The study, “Cytokine polymorphisms in patients with autoimmune hemolytic anemia,” was published in Frontiers in…

A single infusion of one of two doses of SAR445088 — Sanofi’s potential successor to Enjaymo (sutimlimab-jome) — was well-tolerated by people with cold agglutinin disease (CAD) in a small Phase 1b clinical trial. The experimental therapy, also known as riliprubart, appeared to work as expected, with…

BioCryst is working to develop a new oral therapy for cold agglutinin disease (CAD) that suppresses the immune complement cascade, and expects to have a lead candidate selected by 2025. This and other drug development plans were shared recently by the biotech company in a “R&D Day”…

A bipartisan team of congressional representatives is proposing new legislation that aims to make it easier for people with rare disorders like cold agglutinin disease (CAD) to access treatments that may be beneficial even if they haven’t been formally approved for that indication. The legislation — called the…

In people with cold agglutinin disease (CAD), pre-treatment with rituximab and plasma exchange may help limit complications during surgeries where the patient’s body temperature is decreased, a new report illustrates. The case study, “Total arch replacement for an aortic arch aneurysm with cold agglutinin disease after…

In rare cases, cold agglutinin disease (CAD) may develop as a delayed complication of a combination of immune-activating cancer therapies called immune checkpoint inhibitors (ICIs), according to a case report. While some cases of autoimmune hemolytic anemia (AIHA) — a group of autoimmune disorders that include CAD secondary to…

Daratumumab, which is approved to treat some cancers, was effective at controlling cold agglutinin disease (CAD) in an elderly woman who failed to respond to rituximab, a study reports. The report, “Refractory cold agglutinin disease successfully treated with daratumumab. A case report and review of literature,”…

A man had stroke-like symptoms, a heart attack, and rotting skin that were determined to be likely caused by cold agglutinin disease (CAD). While similar issues have been reported with CAD, this may be the first report of these symptoms occurring at the same time in one patient, the…