Patricia Inácio, PhD, science writer —

Most children and adolescents with autoimmune hemolytic anemia (AIHA) — a group of rare conditions that includes cold agglutinin disease (CAD) — respond well to the recommended first-line treatment for adult patients, a study found. The retrospective, single-center study in Brazil found that only a minority of pediatric AIHA…

Infection with SARS-CoV-2, the virus that causes COVID-19, worsened symptoms of cold agglutinin disease (CAD) in a 71-year-old man in whom the autoimmune disease had been stable, a U.S. study reports. This case highlights the need for clinicians to be “mindful of potential preexisting … conditions, particularly [blood-related] diseases,…

A 2-year-old, healthy girl developed a severe, mixed form of autoimmune hemolytic anemia (AIHA) as a result of infection with SARS-CoV-2, the virus that causes COVID-19, a case study reports. While AIHA — a group of rare autoimmune conditions that include cold agglutinin disease (CAD) — secondary to COVID-19…

A case of cold agglutinin disease (CAD) secondary to a type of blood cancer called B-cell lymphoma was confirmed after carefully examining blood samples under the microscope, a study reports. The case study illustrates the “importance of microscopic observation in the exploration of undergoing causes of cold agglutination,” the researchers…

Enrollment for a Phase 1b basket clinical trial of povetacicept (ALPN-303), an experimental anti-inflammatory therapy, for adults with cold agglutinin disease (CAD) and other autoimmune cytopenias is expected to start in the coming months. That’s according to a corporate update from the treatment’s developer, Alpine Immune Sciences. Basket…

Enrollment is underway in a Phase 3 clinical trial testing the investigational therapy pegcetacoplan in adults with primary cold agglutinin disease (CAD), according to a corporate update from the treatment’s developer, Apellis Pharmaceuticals. The trial, called CASCADE (NCT05096403), is enrolling up to 57 patients, 18…

Signs of cold agglutinin disease (CAD) — later found to have been triggered by a previous COVID-19 infection — were detected during heart surgery in a man in Turkey, a case study showed. The case adds to several others reporting developing CAD following COVID-19 disease. Despite being rare,…

A new case study reports the rare co-occurrence of cold agglutinin disease (CAD) and blood cancer in a man in Iran. The patient, 56, who had been diagnosed with myelodysplastic syndrome (MDS), an umbrella term for a group of rare blood cancers, was found to also have CAD…

A woman developed cold agglutinin disease (CAD), with high levels of cold agglutinins sustained for four months after symptom onset following a third dose of a vaccine for SARS-CoV-2, the virus that causes COVID-19, a case report from Japan. According to its authors, “the present case indicates…

Cold agglutinin disease (CAD) patients who take Enjaymo (sutimlimab-jome) long term may continue to experience disease remission after treatment discontinuation, according to a small study of three female patients. Two of the three women — all treated with Enjaymo for at least three years — showed no…