News

Warming methods can aid minor surgeries in CAD patients: Report

A 76-year-old woman with cold agglutinin disease (CAD) underwent an emergency upper endoscopy, a procedure to look at the upper gastrointestinal tract, without any disease-related complications, thanks to warming strategies that prevented her body temperature from getting too low, a study shows. Such strategies included raising the temperature of…

Lymphoma patient develops CAD after receiving COVID-19 vaccine

A man developed cold agglutinin disease (CAD) shortly after receiving a COVID-19 vaccine, which ultimately led to the diagnosis of an underlying blood cancer known as diffuse large B-cell lymphoma (DLBCL), according to a recent case report. While COVID-19 vaccines are considered safe and effective, the authors emphasized the…

Warming strategies prevent surgical complications in woman with CAD

Warming strategies to prevent body temperature from dropping enabled a 42-year-old woman with cold agglutinin disease (CAD) to undergo a hysterectomy under general anesthesia without any disease-related complications, a study shows. “Comprehensive strategies — including measures to promote heat production, maintain core temperature, and prevent redistributive hypothermia — are…

Case of severe CAD emphasizes importance of early diagnosis: Study

A middle-aged woman in Iran with a history of Raynaud’s phenomenon was found to have cold agglutinin disease (CAD) after developing blue-tinged skin, known medically as acrocyanosis, and other severe symptoms, according to a case report highlighting the importance of early diagnosis and treatment in CAD. Raynaud’s…

Woman develops cold agglutinin disease secondary to blood cancer

A 79-year-old woman developed cold agglutinin disease (CAD) secondary to a rare, aggressive type of blood cancer called intravascular large B-cell lymphoma (IVLBCL), a case study reports. B-cell lymphomas are a form of blood cancer that affects B-cells, the type of white blood cell that produces antibodies, including those that…

CAD is most common AIHA type triggered by COVID-19: Review

Cold agglutinin disease (CAD) appears to be the most common type of autoimmune hemolytic anemia (AIHA) — a group of autoimmune diseases marked by attacks on red blood cells — that is triggered by COVID-19, according to a review of published studies. Patients developed AIHA about 13 days after…

CAD treatment riliprubart may be given every 3 months: Study

Riliprubart (SAR445088), a potential successor to Enjaymo (sutimlimab-jome) as a cold agglutinin disease (CAD) treatment, may achieve therapeutic levels with every-three-month dosing at a fixed dose. That’s according to a study that used modeling tools to analyze available clinical trial data and propose an optimal dosing regimen for…

Cold agglutinins linked to lung transplant complications: Study

Nearly half of people without symptoms of cold agglutinin disease (CAD) who undergo a lung transplant test positive for cold agglutinins, the self-reactive antibodies that drive the rare autoimmune condition by targeting red blood cells at low temperatures. That’s according to new data from the first study of its kind…

Epstein-Barr virus infection leads to secondary CAD in girl

A 12-year-old girl in Italy developed cold agglutinin disease (CAD) as a result of an infection with the Epstein-Barr virus (EBV), the virus that causes infectious mononucleosis, a case study reported. Treatment with the corticosteroid methylprednisolone and intravenous immunoglobin (IVIG) progressively led to complete resolution of her CAD symptoms.

Strategies avoid aneurysm surgery complications in 83-year-old man

An 83-year-old man with cold agglutinin disease (CAD) underwent surgery for an abdominal aortic aneurysm — a bulging in the lower part of the aorta, the body’s largest blood vessel — without major complications thanks to several preventive strategies, a study reported. To avoid complications from cold-induced hemolysis, or…