The detection of cold agglutinins, the self-reactive antibodies that drive cold agglutinin disease (CAD), was crucial for the correct diagnosis and management of anemia — lower than normal levels of red blood cells or hemoglobin — in a 37-year-old man with several traumatic injuries after a motorcycle accident, according…
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In a young girl in India, cold agglutinin disease (CAD) secondary to a respiratory infection resulted in symptoms suggestive of vasculitis, a group of conditions marked by blood vessel inflammation, a study reported. The symptoms mimicking vasculitis included blueish-blackish discoloration of the nose’s tip that indicated tissue cell death…
Nearly 18% of people with autoimmune hemolytic anemia (AIHA), of which cold agglutinin disease (CAD) is one type, were hospitalized due to an infection within six months of their first rituximab infusion, according to a French study. Patients particularly at risk for infection-related hospitalizations were those older than…
A 50-year-old woman developed cold agglutinin disease (CAD) secondary to two different types of cancer within the thyroid gland, a study reported. The surgical removal of the thyroid gland successfully treated both the cancer and CAD. While CAD has been reported to occur secondary to blood cancers, it is…
A woman in Costa Rica developed cold agglutinin disease (CAD) secondary to a diagnosis of systemic lupus erythematosus (SLE) that was complicated by nephritis, a serious kidney inflammation that often occurs with this form of lupus. CAD “is exceptionally rare in SLE, with few cases being reported in…
Managing the life-threatening consequences of a rare autoimmune condition called ANCA-associated vasculitis (AAV) can be particularly challenging when cold agglutinin disease (CAD) is also present, according to a recent case report. In this first documented case of AAV co-occurring with CAD, scientists described how the cold temperature of…
Enjaymo (sutimlimab) was effective at controlling signs and symptoms of cold agglutinin disease (CAD) in a man in his 70s being given dialysis for kidney failure, a study in Japan reports. “To the best of our knowledge, this is the first report of CAD in a patient undergoing…
Long-term treatment with Enjaymo (sutimlimab) leads to sustained reductions in red blood cell destruction, anemia, and fatigue, as well as life quality improvements, in adults with cold agglutinin disease (CAD). That’s according to data from the extension portion (Part B) of the global Phase 3 CADENZA clinical…
A Japanese woman developed cold agglutination disease (CAD) following COVID-19 and a secondary bacterial infection in the lungs that may have worsened her symptoms, a case study showed. “There is a need for continuous observation to evaluate whether COVID-19, even when it does not require hospitalization, is related to…
Distinguishing between primary and secondary cold agglutinin disease (CAD), as well as understanding if cancer is the underlying cause of secondary CAD, is critical to ensure patients get the right treatment, according to a recent review study. Primary CAD — sometimes known simply as CAD — is not…
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