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In rare cases, cold agglutinin disease (CAD) may develop as a delayed complication of a combination of immune-activating cancer therapies called immune checkpoint inhibitors (ICIs), according to a case report. While some cases of autoimmune hemolytic anemia (AIHA) — a group of autoimmune disorders that include CAD secondary to…

Diagnosis and treatment of cold agglutinin disease (CAD) secondary to a type of blood cancer was complicated by COVID-19 in a middle-aged man, a case study reports. The researchers identified specific mutations in immune cells that may explain the “treatment resistance and susceptibility to COVID-19,” they wrote in the…

A young woman in Colombia developed cold agglutinin disease (CAD) secondary to systemic lupus erythematosus (SLE), an autoimmune disease often called lupus, a study reports. While other types of autoimmune hemolytic anemia (AIHA) — rare autoimmune diseases marked by self-reactive antibodies attacking and destroying red blood cells —…

Daratumumab, which is approved to treat some cancers, was effective at controlling cold agglutinin disease (CAD) in an elderly woman who failed to respond to rituximab, a study reports. The report, “Refractory cold agglutinin disease successfully treated with daratumumab. A case report and review of literature,”…

A man with cold agglutinin disease (CAD) had significant red blood cell clumping in his coronary arteries during a procedure to correct an abnormal heart rhythm, blocking blood supply to the heart, according to a recent case report. Researchers called this “a novel and unusual manifestation” of CAD that…

Atypical symptoms, including persistent blue discoloration and skin lesions in the extremities, along with uncommon laboratory findings, delayed a cold agglutinin disease (CAD) diagnosis for more than a decade in a 60-year-old woman, a study reports. “This case adds important context to the difficulty in diagnosis of this disease,”…

A case of cold agglutinin disease (CAD) secondary to a type of blood cancer called B-cell lymphoma was confirmed after carefully examining blood samples under the microscope, a study reports. The case study illustrates the “importance of microscopic observation in the exploration of undergoing causes of cold agglutination,” the researchers…

A man had stroke-like symptoms, a heart attack, and rotting skin that were determined to be likely caused by cold agglutinin disease (CAD). While similar issues have been reported with CAD, this may be the first report of these symptoms occurring at the same time in one patient, the…

For a toddler in Brazil, cold agglutinin disease (CAD) occurred secondary to an infection with an adenovirus, a common virus that can cause symptoms similar to a cold or the flu, a case study reports. According to the researchers, this represents “the first pediatric case of cold agglutinin syndrome…

A case of cold agglutinin disease (CAD), found to be secondary to a type of blood cancer called B-cell lymphoma, successfully resolved after the cancer was appropriately treated, a study shows. The case report illustrates the importance of identifying the underlying cause of CAD so treatment can be given,…