News

Youngest case of primary CAD reported

A rituximab-based therapy regimen successfully treated a 16-year-old girl with primary cold agglutinin disease (CAD), according to researchers in the U.S. who say the case represents “the youngest patient reported with this diagnosis.” The case study, “An unusual case of primary cold agglutinin-associated lymphoproliferative disease…

Enjaymo over 2.5 years seen to reduce anemia, fatigue in CAD

Long-term treatment with Enjaymo (sutimlimab-jome) in people with cold agglutinin disease (CAD) results in rapid and sustained reductions in red blood cell destruction and anemia, as well as clinically-meaningful reductions in fatigue. That’s according to 2.5 years of data from the Phase 3 CARDINAL clinical trial, which tested…

Therapy targeting CAD self-reactive antibodies shows promise in lab

An experimental treatment called HMBD-011, designed to target self-reactive antibodies and the immune B-cells that produce them, showed efficacy in a cellular model of cold agglutinin disease (CAD), according to new preclinical findings presented at a scientific conference. “HMBD-011 is a potentially first-in-class … antibody developed for treatment for…

CAD symptoms, daily impacts recorded in new patient assessment

Researchers have developed a new patient-reported outcome questionnaire to assess symptoms and the impacts to daily life associated with cold agglutinin disease (CAD). Called the CAD-Symptoms and Impact Questionnaire (CAD-SIQ), it was developed by analyzing responses from patient interviews. Reactions to cold environments and fatigue were the most commonly…

CAD diagnosed during emergency heart surgery in woman

The induced reduction in body temperature during an emergency surgery to replace a damaged heart component revealed the presence of mild cold agglutinin disease (CAD) in a woman in India, a study reports. The case study, “Cardiopulmonary Bypass Surgery-Cold Alert!,” was published in Annals of Cardiac Anaesthesia.