A new tablet formulation of Annexon Biosciences’ experimental therapy ANX1502 resulted in therapy levels in the blood that surpassed those expected to be effective in fasting participants with cold agglutinin disease (CAD). These results from a proof-of-concept study reflect a promising pharmacokinetic profile, which describes how the medication…
News
Cold agglutinin disease (CAD) secondary to Mycoplasma pneumoniae (M. pneumoniae) infection in adults is linked to severe illness, including a high risk of complications related to blood clots and intensive care admissions, according to a national study in France. Still, data showed that most patients recover within weeks with…
A teenage girl in the U.K. was treated after developing cold agglutinin disease (CAD) as a rare complication of systemic lupus erythematosus (SLE), the most common form of the autoimmune disease lupus. CAD is a type of autoimmune hemolytic anemia (AIHA) that’s marked by immune attacks against red…
A dental infection triggered an attack of red blood cell destruction, or hemolysis, in a man in his 40s with cold agglutinin disease (CAD), according to a case report from Japan that, researchers say, highlights the need for CAD patients to maintain good oral hygiene. Previous studies have reported…
Treatment with rituximab — commonly used off-label for cold agglutinin disease (CAD) — was found to improve biomarkers of red blood cell destruction in people with CAD, but these benefits were often short-term and reversed within a few months, according to a real-world study in the U.S. The study also…
Thrombotic events (TE), or the blockage of blood flow due to blood clots, are relatively common among adults with cold agglutinin disease (CAD) and other forms of autoimmune hemolytic anemia (AIHA), according to a study in France. Researchers also found that experiencing five or more hemolytic attacks marked by…
Up to about 1 person in 100,000 in the U.S. is estimated to be diagnosed with primary cold agglutinin disease (CAD) each year and up to 3 in 10,000 people are living with the disease, a study that analyzed 2016-2023 data from national claim databases suggests. Primary CAD…
A 76-year-old woman with cold agglutinin disease (CAD) underwent an emergency upper endoscopy, a procedure to look at the upper gastrointestinal tract, without any disease-related complications, thanks to warming strategies that prevented her body temperature from getting too low, a study shows. Such strategies included raising the temperature of…
A man developed cold agglutinin disease (CAD) shortly after receiving a COVID-19 vaccine, which ultimately led to the diagnosis of an underlying blood cancer known as diffuse large B-cell lymphoma (DLBCL), according to a recent case report. While COVID-19 vaccines are considered safe and effective, the authors emphasized the…
Warming strategies to prevent body temperature from dropping enabled a 42-year-old woman with cold agglutinin disease (CAD) to undergo a hysterectomy under general anesthesia without any disease-related complications, a study shows. “Comprehensive strategies — including measures to promote heat production, maintain core temperature, and prevent redistributive hypothermia — are…
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