A woman with hard-to-treat cold agglutinin disease (CAD) was later found to have high-grade gastric B-cell lymphoma — a type of blood cancer that originates in the stomach — and treating that cancer was key to controlling her CAD symptoms, a case report shows. The lymphoma, which turned out…
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A proof-of-concept study designed to test a new tablet formulation of the experimental therapy ANX1502 in people with cold agglutinin disease (CAD) is continuing dosing to provide further insights into the therapy’s pharmacological profile and its impact on disease biomarkers. Data so far have been promising, showing that blood…
A 44-year-old man with cold agglutinin disease (CAD) secondary to lymphoplasmacytic lymphoma, a type of blood cancer, recovered quickly after starting iptacopan, an oral therapy that targets the complement system, together with lymphoma treatment, a study showed. The complement cascade is a part of the immune system that contributes…
A 64-year-old man in Iran developed cold agglutinin disease (CAD) secondary to acute myeloid leukemia (AML), a type of blood cancer, a case study reports. The blood cancer was detected only after the man started to experience CAD symptoms and a biopsy of the bone marrow, the spongy tissue in which…
A U.S. man in his 60s developed cold agglutinin disease (CAD) as a rare complication of advanced pancreatic cancer, a case study reports. While CAD has been increasingly found to occur secondary to blood cancers, it is rarely associated with solid tumors. That may make treatment challenging…
While autoimmune hemolytic anemia (AIHA) — a group of disorders that includes cold agglutinin disease (CAD) — shares some immune features with other red blood cell-targeting diseases, its unique features might help researchers develop targeted therapies, a study reports. When analyzing the repertoire of immune B- and T-cell receptor…
A young girl developed cold agglutinin disease (CAD) secondary to a bacterial lung infection, due to Mycoplasma pneumoniae (M. pneumoniae), that resulted in progressive tissue death in her nose and limb extremities, according to a case report from Iran. The child’s condition did not respond to typical therapies aimed…
Laboratories testing for cold agglutinins — the self-reactive antibodies causing cold agglutinin disease (CAD) — need to use standard protocols to provide accurate results, compare results between studies, and guide treatment, researchers said. “International standardization of CA [cold agglutinin] testing for diagnostic use is essential,” the researchers wrote.
An underlying disorder involving abnormal cell growth turned out to be at the root of cold agglutinin disease (CAD) in a 78-year-old woman. The woman had monoclonal B-cell lymphocytosis (MBL), a condition that occurs when a group of identical white blood cells, in this case B-cells, grows abnormally, a…
The glucocorticoid prednisolone successfully treated a man’s primary cold agglutinin disease (CAD), which is typically resistant to such therapies, a case report said. “Occasional” primary CAD cases “have demonstrated a favorable response” to glucocorticoids, “highlighting the need for a flexible and individualized therapeutic approach,” the researchers wrote. The case…
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