CAD symptoms, daily impacts recorded in new patient assessment

Researchers have developed a new patient-reported outcome questionnaire to assess symptoms and the impacts to daily life associated with cold agglutinin disease (CAD). Called the CAD-Symptoms and Impact Questionnaire (CAD-SIQ), it was developed by analyzing responses from patient interviews. Reactions to cold environments and fatigue were the most commonly…

CAD diagnosed during emergency heart surgery in woman

The induced reduction in body temperature during an emergency surgery to replace a damaged heart component revealed the presence of mild cold agglutinin disease (CAD) in a woman in India, a study reports. The case study, “Cardiopulmonary Bypass Surgery-Cold Alert!,” was published in Annals of Cardiac Anaesthesia.

No gains in transfusion efficacy with C1-INH treatment for CAD

A treatment to reduce the activation of the immune complement system didn’t increase the effectiveness of red blood cell transfusions in people with severe cold agglutinin disease (CAD) and other complement-mediated autoimmune hemolytic anemia (CM-AIHA). That’s according to a small, proof-of-concept Phase 2 clinical trial (EudraCT2012-003710-13) that found…