Cold agglutinin disease (CAD) rarely occurs without abnormal immune cell growth in the bone marrow or blood, but this abnormal cell growth is often hard to detect with standard assessments, a new study shows. “Our data underscore the importance of a comprehensive and sensitive approach when evaluating bone marrow…
Discussion
I parked my car with a feeling of déjà vu. This was my sixth trip to the hospital this year. I wanted to wait to be seen by my medical team, but my fever kept rising, so I decided to go to the emergency room. It was the first time…
Enjaymo (sutimlimab-jome) rapidly and sustainably reduces red blood cell destruction and the need for blood transfusions in most adults with hard-to-treat cold agglutinin disease (CAD) in real-world clinical settings, a study showed. “[Enjaymo] demonstrated rapid, durable effectiveness and a favorable safety profile in heavily pretreated real-world CAD patients,”…
Primary cold agglutinin disease (CAD) is not a single, uniform disease and can be difficult to distinguish from certain blood cancers, making it challenging to diagnose using standard criteria, a study in Japan suggests. Researchers found that, even after excluding cases linked to underlying conditions — known as cold…
Discussion
My husband, Mike, and I started our stewardship of the family home in 2004. Mom had died earlier that year and Dad wanted to provide a home for his wandering child. The house was stuffed with family treasures. Since Mom had been a hoarder in her latter years, there was…
Cold agglutinin disease (CAD) is a rare disorder in which the immune system mistakenly attacks red blood cells, resulting in anemia.
CAD is characterized by autoantibodies, called cold agglutinins, binding to and activating the destruction of red blood cells when exposed to cold temperatures.
Symptoms of CAD include fatigue, Raynaud’s syndrome, joint pain, jaundice or skin discoloration, and heart problems. These symptoms can worsen with more cold exposure.
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