Rituximab helped improve signs and symptoms of cold agglutinin disease (CAD) occurring alongside acquired hemophilia A, another autoimmune blood disorder, in a 53-year-old man in China, a case report describes. In CAD, the immune system mistakenly attacks red blood cells, while in acquired hemophilia A, it targets factor…
A new case series urges clinicians to keep cold agglutinin disease (CAD) on their radar when treating elderly patients with unexplained anemia. Researchers say that because the rare autoimmune condition often occurs with “clinically subtle” or atypical symptoms, it can easily be missed, delaying essential treatment for underlying causes…
Discussion
Editor’s note: This story includes discussion of suicide. If you or someone you know needs help, the national suicide and crisis lifeline in the U.S. is available by calling or texting 988. There is also an online chat at 988lifeline.org. Internationally, find a suicide prevention…
The U.S. Food and Drug Administration (FDA) has granted fast-track designation to Ouro Medicines’ experimental treatment gamgertamig for autoimmune hemolytic anemia (AIHA), a group of autoimmune diseases that includes cold agglutinin disease. Fast-track designation is intended to accelerate the development and review of potential treatments for serious diseases…
People with cold agglutinin disease (CAD) treated long-term with Enjaymo (sutimlimab-jome) maintained stable hemoglobin levels, avoided blood transfusions, and showed sustained reductions in red blood cell destruction for nearly two years, according to a real-world, single-center study from Germany. “The present small, [single-center]…
Cold agglutinin disease (CAD) is a rare disorder in which the immune system mistakenly attacks red blood cells, resulting in anemia.
CAD is characterized by autoantibodies, called cold agglutinins, binding to and activating the destruction of red blood cells when exposed to cold temperatures.
Symptoms of CAD include fatigue, Raynaud’s syndrome, joint pain, jaundice or skin discoloration, and heart problems. These symptoms can worsen with more cold exposure.
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