Certain variations in genes that encode cytokines — signaling molecules involved in immune responses — may predispose people toward the development of cold agglutinin disease (CAD), a new study suggests. The study, “Cytokine polymorphisms in patients with autoimmune hemolytic anemia,” was published in Frontiers in…

Fetal complications are about four times more common in pregnant women with autoimmune hemolytic anemia (AIHA), including cold agglutinin disease (CAD), than in those without the autoimmune condition, according to a small study. Still, maternal complications occurred at similar rates, and most were directly linked to AIHA relapses, or…

Physicians should be aware that patients with autoimmune hemolytic anemia (AIHA) are at greater risk of experiencing thrombotic events — blood vessel obstruction driven by blood clots — to better manage their condition, a case report highlighted. The case study, “Autoimmune Hemolytic…

Japanese patients with cold agglutinin disease (CAD) are almost three times more likely to develop blood clots compared with people without this autoimmune disorder, a study reports. These findings are in agreement with the results for non-Asian populations, according to the researchers. The study, “Demographic characteristics, thromboembolism…

The risk of blood clots nearly doubles in people with cold agglutinin disease (CAD) compared with that seen in patients with other conditions, a large data study from the U.S. reports. “Increased risk of thrombotic events in cold agglutinin disease: A 10-year retrospective analysis” was published in the…

Cold agglutinin disease (CAD) is a rare disorder in which the body mistakenly produces antibodies against its own red blood cells. In colder temperatures, these antibodies bind to the red blood cells and target them for destruction. CAD can cause a problem for heart surgery patients. That’s why…

Cold agglutinin disease (CAD) patients have an increased risk of developing blood clots compared to the general population, a retrospective Danish study shows. The findings of the study, “Occurrence, thromboembolic risk, and mortality in Danish patients with cold agglutinin disease” were published recently in the journal Blood Advances. In…

To lower the risk of meningitis infection in patients with cold agglutinin disease (CAD) treated with Soliris (eculizumab), a booster given shortly after the first vaccination may be required, a study suggests. Because patients who receive therapies that target the complement system — such as Soliris — are…

Immune rejection and half-matched donors are risk factors for developing autoimmune hemolytic anemia (AIHA) following blood cancer-treating stem cell transplants, a study found. Titled “Autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation in adults: A southern China multicenter experience,” the study was published in the…