For a toddler in Brazil, cold agglutinin disease (CAD) occurred secondary to an infection with an adenovirus, a common virus that can cause symptoms similar to a cold or the flu, a case study reports. According to the researchers, this represents “the first pediatric case of cold agglutinin syndrome…
A case of cold agglutinin disease (CAD), found to be secondary to a type of blood cancer called B-cell lymphoma, successfully resolved after the cancer was appropriately treated, a study shows. The case report illustrates the importance of identifying the underlying cause of CAD so treatment can be given,…
Long-term treatment with Enjaymo (sutimlimab-jome) led to sustained improvements in life quality and reductions in fatigue for people with cold agglutinin disease (CAD), according to 2.5 years of data from the Phase 3 CARDINAL clinical trial. “[Enjaymo] provides sustained and durable treatment benefits in chronic CAD, including a…
Two approved blood cancer treatments, daratumumab and bortezomib, were each partially effective at reducing signs of cold agglutin disease (CAD) in two people with hard-to-treat cases of the autoimmune disorder, a study showed. These two therapies, alone or in combination, also were found to effectively treat five of six people with other…
Legionnaires’ disease — a lung infection caused by a group of bacteria called Legionella — caused secondary cold agglutinin disease (CAD) in a 40-year-old man, a case study reports. The case, which represents the second reported case of CAD secondary to Legionnaires’ disease, suggest doctors should consider this infection…
Sanofi’s experimental therapy SAR445088 effectively blocks the classic complement pathway — a part of the immune system that’s implicated in cold agglutinin disease (CAD) — and reduced red blood cell destruction in a cellular model of CAD, a study showed. SAR445088’s more targeted action may make it a…
A woman with a mixed form of autoimmune hemolytic anemia (AIHA), who was having only temporary responses to standard treatment, experienced complete disease remission after being given an interleukin-23 (IL-23) inhibitor for a separate condition, a case study shows. IL-23 inhibitor therapies are used for other inflammatory diseases, but have…
Specially designed miniaturized antibodies, or nanobodies, reduced blood cell destruction in a new mouse model of a disease similar to cold agglutinin disease (CAD), a study showed. These findings suggest that the nanobodies, designed to suppress the complement cascade by blocking the complement component 2 (C2) protein, could…
A young woman developed cold agglutinin disease (CAD) secondary to pneumonia, but responded well to red blood cell transfusions and treatment with the antibiotic doxycycline, according to a U.S. report. When CAD occurs secondary to an infection, “supportive therapy and treatment of the underlying infection is sufficient,” researchers…
A rituximab-based therapy regimen successfully treated a 16-year-old girl with primary cold agglutinin disease (CAD), according to researchers in the U.S. who say the case represents “the youngest patient reported with this diagnosis.” The case study, “An unusual case of primary cold agglutinin-associated lymphoproliferative disease…
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