Marisa Wexler, MS, senior science writer —

COVID-19 can worsen symptoms of cold agglutinin disease (CAD), a recent case report highlights. The scientists stressed the need for further research to determine the best ways to care for people with new or worsening CAD that develops in the context of a COVID-19 infection. In this case, treatment…

The U.S. Food and Drug Administration (FDA) has approved Enjaymo (sutimlimab-jome) to decrease the need for red blood cell transfusions due to hemolysis, or red blood cell destruction, in adults with cold agglutinin disease (CAD). Enjaymo, which works by preventing hemolysis, is the first and only FDA-approved therapy…

A bone marrow biopsy may be useful as a test for an underlying cancer or other conditions involving the excessive immune cell expansion and guiding treatment in people with newly diagnosed cold agglutinin disease (CAD), according to a new study. The study, “The Role of a…

People with cold agglutinin disease (CAD) show signs of red blood cell destruction year round, not just when the weather is cold, a new study highlights. These findings suggest that CAD patients should be closely monitored at all times, regardless of season, according to researchers. The study, “…

In some cases, vaccines for COVID-19 can lead to a disease flare in people with cold agglutinin disease (CAD) and related conditions, but these flares can be readily managed with proper treatment, according to an Italian study. These findings point to a need for close monitoring when these patients…

Cold agglutinin disease (CAD) and not the cancer therapy Keytruda (pembrolizumab) was found to be the cause of anemia in a 64-year-old man with lung cancer, according to a recent case report. The patient’s CAD arose as a result of another type of cancer — a lymphoma —…

Eurordis opened a campaign, called Rare 2030 Action, that is seeking to establish a European action plan for rare diseases to ensure that none of the 30 million people in Europe living with rare diseases are left behind by the start of a new decade. As part of…

The case of an 80-year-old man with cold agglutinin disease (CAD) who underwent abdominal surgery to remove his gallbladder was described in a recent report. Its investigators highlighted steps that can be taken to minimize the risk of CAD-related complications during surgery, such as increasing the temperature of the…

Cold agglutinin disease (CAD) is more frequently diagnosed during winter months at multiple locations across Europe, supporting outdoor temperature as a disease trigger, researchers reported. Findings also suggest that, in general, people living in places with milder weather may be less likely to experience CAD symptoms and, as such,…

The case of a man with COVID-19 who temporarily developed elevated levels of cold agglutinins — the self-reactive antibodies that cause cold agglutinin disease (CAD) — was described in a recent report. According to researchers, this is the third known case of elevated cold agglutinin levels documented in…