Lindsey Shapiro, PhD,  science writer—

A woman with a mixed form of autoimmune hemolytic anemia (AIHA), who was having only temporary responses to standard treatment, experienced complete disease remission after being given an interleukin-23 (IL-23) inhibitor for a separate condition, a case study shows. IL-23 inhibitor therapies are used for other inflammatory diseases, but have…

Researchers have developed a new patient-reported outcome questionnaire to assess symptoms and the impacts to daily life associated with cold agglutinin disease (CAD). Called the CAD-Symptoms and Impact Questionnaire (CAD-SIQ), it was developed by analyzing responses from patient interviews. Reactions to cold environments and fatigue were the most commonly…

Dianthus Therapeutics plans to launch a proof-of-concept clinical trial of its therapy candidate DNTH103 in 2024 to test the efficacy of the complement inhibitor in people with cold agglutinin disease (CAD). Data from the trial would be expected in the second half of next year. Funding for the…

Among people who meet the criteria for a blood condition called IgM monoclonal gammopathy of undetermined significance (IgM-MGUS), those with cold agglutinin disease (CAD) show distinct clinical and laboratory features from those without, a study shows. IgM-MGUS is marked by the excessive production of immunoglobulin M (IgM), a type…

A treatment to reduce the activation of the immune complement system didn’t increase the effectiveness of red blood cell transfusions in people with severe cold agglutinin disease (CAD) and other complement-mediated autoimmune hemolytic anemia (CM-AIHA). That’s according to a small, proof-of-concept Phase 2 clinical trial (EudraCT2012-003710-13) that found…

Fetal complications are about four times more common in pregnant women with autoimmune hemolytic anemia (AIHA), including cold agglutinin disease (CAD), than in those without the autoimmune condition, according to a small study. Still, maternal complications occurred at similar rates, and most were directly linked to AIHA relapses, or…

Individuals with cold agglutinin disease (CAD) face greater risks of mental health problems, with patients 60% more likely than healthy people to receive medical attention for anxiety or depression, according to a new U.S. study. The data referred to a combined risk of requiring either a hospital visit for…

Patients who develop cold agglutinin antibodies after COVID-19 infection won’t always show overt signs of cold agglutinin disease (CAD), a case report suggested. Two patients with COVID-19 at a clinic in Japan had high levels of the antibodies, but didn’t show signs of red blood cell destruction (hemolytic anemia)…

A man’s cold agglutinin disease (CAD) was caused by a type of blood cancer called B-lymphoblastic leukemia, according to a recent case report. While cancer is a known cause of CAD, this type of cancer was unexpected, the researchers noted, adding that a full work-up is needed to ensure…

Enjaymo (sutimlimab) quickly led to increases in hemoglobin and lowered the need for blood transfusions in four women with cold agglutinin disease (CAD), in whom the treatment remained safe and effective for about three years, according to data from a Phase 1 open-label extension trial. Trial data was…