News

Few cases of cold agglutinin disease (CAD) secondary to systemic lupus erythematosus, or SLE, have been reported over the past seven decades, but all occurred in women, according to a study by two researchers in Colombia. In addition to describing two new cases of CAD secondary to SLE —…

Clinicians detected B-cell lymphoma, a type of blood cancer, in a 53-year-old man two years after he was diagnosed with cold agglutinin disease (CAD) marked by anemia, or low counts of red blood cells, but no symptoms, a case study indicates. All signs of lymphoma and CAD disappeared after…

Cold agglutinin disease (CAD) was the likely cause of blood clot formation during brain surgery in a 57-year-old man, despite measures to prevent his body temperature from getting too low, a case study in Turkey showed. Because the clot occurred at the site where two brain blood vessels were…

A boy in China was diagnosed with a rare case of cold agglutinin disease (CAD) associated with a Mycoplasma pneumoniae lung infection and a pulmonary embolism, which is a blood clot in the arteries that supply the lungs, according to a new case report. After treatment with antibiotics,…

A 50-year-old woman in the U.S. developed secondary cold agglutinin disease (CAD), a rare form of autoimmune anemia, as a complication of advanced breast cancer, a case study detailed. The researchers acknowledged that CAD “is rarely secondary to solid tumors,” as are typically seen in breast cancer. But they…

A man with rheumatoid arthritis and cold agglutinin disease (CAD) achieved complete remission following treatment with rituximab, an antibody-based therapy commonly used off-label for CAD, a recent case study indicates. Rituximab therapy also treated the man’s cooccurring immune thrombocytopenia, an autoimmune disorder marked by the destruction of platelets, which…

A Japanese man with severe anemia — a condition marked by too few red blood cells in the body — following a case of COVID-19 tested positive for cold agglutinins and cryoglobulins, two types of antibodies that become reactive in the cold, according to a new report. Cold agglutinins are…

Very low doses of rituximab rapidly reduced blood levels of disease-driving B-cells in people with cold agglutinin disease (CAD) and other forms of autoimmune hemolytic anemia (AIHA), but this suppression was not consistently sustained over time. Those are the findings of a small pilot Phase 2 clinical…

Warming and an extra dose of corticosteroid medication were part of multiple strategies doctors used to allow for a safe Cesarean section (c-section), without complications, in a pregnant woman with cold agglutinin disease (CAD), according to a case report. The woman was kept warm right during her hospital stay,…

Cold agglutinin disease (CAD) was the likely trigger of repeated mini-strokes in an 84-year-old woman with already compromised blood flow in the brain due to severe narrowing of a major artery that supplies blood to the brain, according to a case report from Portugal. The underlying mechanisms of red…