News

No gains in transfusion efficacy with C1-INH treatment for CAD

A treatment to reduce the activation of the immune complement system didn’t increase the effectiveness of red blood cell transfusions in people with severe cold agglutinin disease (CAD) and other complement-mediated autoimmune hemolytic anemia (CM-AIHA). That’s according to a small, proof-of-concept Phase 2 clinical trial (EudraCT2012-003710-13) that found…

Annexon planning proof-of-concept study of ANX1502 for CAD this year

A Phase 1 trial testing Annexon Biosciences’ oral treatment candidate ANX1502 — for complement-mediated autoimmune disorders such as cold agglutinin disease (CAD) — in healthy volunteers has moved to its multiple-dosing phase. The company is planning to launch a proof-of-concept study of ANX1502 in people with CAD later…

Woman diagnosed with CAD after having chickenpox: Case report

The rare case of a young woman with cold agglutinin disease (CAD) secondary to chickenpox, also known as varicella, was described in a recent report in India. While corticosteroids, a type of steroid, are usually not recommended for CAD secondary to an infection, the rapid and sustained red blood…

Intractable primary CAD managed successfully with splenectomy

Splenectomy, or the surgical removal of the spleen, significantly reduced unmanageable red blood cell destruction in a man with primary cold agglutinin disease (CAD), a study showed. While this approach is usually considered to be ineffective in CAD patients, this case report adds to other studies where  CAD was successfully…

Healthy Pregnancy With AIHA Is Possible But Carries Risks: Study

Fetal complications are about four times more common in pregnant women with autoimmune hemolytic anemia (AIHA), including cold agglutinin disease (CAD), than in those without the autoimmune condition, according to a small study. Still, maternal complications occurred at similar rates, and most were directly linked to AIHA relapses, or…