The oral medication iptacopan — approved for certain blood and complement-related conditions — helped alleviate anemia in most people with cold agglutinin disease (CAD) in a small Phase 2 clinical trial, according to study. The complement cascade is a component of the immune system that contributes to the hemolysis,…
News
Enjaymo (sutimlimab-jome) remains safe to use over the long term, according to new real-world data from adults with primary or secondary cold agglutinin disease (CAD) who have been taking the approved medication for an average of more than two years. The data come from CADENCE (NCT05791708), an…
A bacterial lung infection caused by Mycoplasma pneumoniae— a very small cell bacterium known as M. pneumoniae for short — triggered cold agglutinin disease (CAD) and severe blood clotting in a man in his late 50s, according to a case report from the U.S. The man recovered after treatment…
A woman with hard-to-treat cold agglutinin disease (CAD) was later found to have high-grade gastric B-cell lymphoma — a type of blood cancer that originates in the stomach — and treating that cancer was key to controlling her CAD symptoms, a case report shows. The lymphoma, which turned out…
A proof-of-concept study designed to test a new tablet formulation of the experimental therapy ANX1502 in people with cold agglutinin disease (CAD) is continuing dosing to provide further insights into the therapy’s pharmacological profile and its impact on disease biomarkers. Data so far have been promising, showing that blood…
A 44-year-old man with cold agglutinin disease (CAD) secondary to lymphoplasmacytic lymphoma, a type of blood cancer, recovered quickly after starting iptacopan, an oral therapy that targets the complement system, together with lymphoma treatment, a study showed. The complement cascade is a part of the immune system that contributes…
A 64-year-old man in Iran developed cold agglutinin disease (CAD) secondary to acute myeloid leukemia (AML), a type of blood cancer, a case study reports. The blood cancer was detected only after the man started to experience CAD symptoms and a biopsy of the bone marrow, the spongy tissue in which…
A U.S. man in his 60s developed cold agglutinin disease (CAD) as a rare complication of advanced pancreatic cancer, a case study reports. While CAD has been increasingly found to occur secondary to blood cancers, it is rarely associated with solid tumors. That may make treatment challenging…
While autoimmune hemolytic anemia (AIHA) — a group of disorders that includes cold agglutinin disease (CAD) — shares some immune features with other red blood cell-targeting diseases, its unique features might help researchers develop targeted therapies, a study reports. When analyzing the repertoire of immune B- and T-cell receptor…
A young girl developed cold agglutinin disease (CAD) secondary to a bacterial lung infection, due to Mycoplasma pneumoniae (M. pneumoniae), that resulted in progressive tissue death in her nose and limb extremities, according to a case report from Iran. The child’s condition did not respond to typical therapies aimed…
Recent Posts
- Oral therapy iptacopan eases anemia in CAD patients: Small trial
- When living with CAD, even a short trip can be a nightmare
- Real-world study confirms long-term safety of Enjaymo for CAD
- After months of fatigue, feeling better is what I want for Christmas
- Man’s case shows bacterial lung infection can ‘provoke’ clots, CAD
- Living with cold agglutinin disease involves cruel curveballs
- Gastric lymphoma found to be hidden cause of refractory CAD
- New CAD treatments, like reading progress, prove growth is possible
- ANX1502 proof-of-concept trial to wrap up next year, Annexon says
- What if Sadie Hawkins Day made me the doctor?