News

An 83-year-old woman with cold agglutinin disease (CAD) had knee surgery under local spinal anesthesia without any disease-related complications as a result of significant warming strategies to prevent her body temperature from getting too low, a study shows. During and after the surgery, the woman’s body temperature remained stable…

A woman in Taiwan likely developoed cold agglutinin disease (CAD) secondary to advanced diffuse large B-cell lymphoma (DLBCL), a type of fast-growing blood cancer that begins in immune B-cells, a study reports. This case adds to a growing, but still small, number of reports linking the two diseases. “We…

A woman with cold agglutinin disease (CAD) developed a rare type of kidney damage caused by the accumulation of faulty antibodies inside small blood vessels, a case study shows. This accumulation is also known as intracapillary deposits of monoclonal immunoglobulin M (IgM) antibodies. “To the best of our knowledge,…

A woman in Sri Lanka likely developed secondary cold agglutinin disease (CAD) that resulted from a rare type of “unusual and clinically aggressive” diffuse large B-cell lymphoma, a fast-growing blood cancer that formed in immune B-cells and involved the bone marrow, liver, and spleen. The case is the first…

The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale, a widely used questionnaire to assess fatigue, is reliable, valid, and responsive to changes in the severity of cold agglutinin disease (CAD), according to a study. The findings relied on CAD patients’ impressions of the FACIT-Fatigue scale and data from…

Annexon Biosciences’ new tablet formulation of its experimental therapy ANX1502 reduced key clinical and biomarker measures in the three cold agglutinin disease (CAD) patients so far enrolled in a proof-of-concept clinical trial. “In patients treated with the oral small molecule ANX1502, we are encouraged by the changes in…

An autologous stem cell transplant (ASCT) to treat lymphoma, a blood cancer, was safely performed in a man with severe cold agglutinin disease (CAD) who was dependent on blood transfusions, researchers in Canada have reported. Several strategies for a successful transplant were used to avoid potential complications from…

Nearly half of children and teens with autoimmune hemolytic anemia (AIHA) — a group of disorders that includes cold agglutinin disease (CAD)  — have signs of erythrophagocytosis, or the removal of old and damaged red blood cells by immune cells, in blood samples, a small study shows. While erythrophagocytosis…

Few cases of cold agglutinin disease (CAD) secondary to systemic lupus erythematosus, or SLE, have been reported over the past seven decades, but all occurred in women, according to a study by two researchers in Colombia. In addition to describing two new cases of CAD secondary to SLE —…

Clinicians detected B-cell lymphoma, a type of blood cancer, in a 53-year-old man two years after he was diagnosed with cold agglutinin disease (CAD) marked by anemia, or low counts of red blood cells, but no symptoms, a case study indicates. All signs of lymphoma and CAD disappeared after…