Nearly half of people without symptoms of cold agglutinin disease (CAD) who undergo a lung transplant test positive for cold agglutinins, the self-reactive antibodies that drive the rare autoimmune condition by targeting red blood cells at low temperatures. That’s according to new data from the first study of its kind…
A 12-year-old girl in Italy developed cold agglutinin disease (CAD) as a result of an infection with the Epstein-Barr virus (EBV), the virus that causes infectious mononucleosis, a case study reported. Treatment with the corticosteroid methylprednisolone and intravenous immunoglobin (IVIG) progressively led to complete resolution of her CAD symptoms.
An 83-year-old man with cold agglutinin disease (CAD) underwent surgery for an abdominal aortic aneurysm — a bulging in the lower part of the aorta, the body’s largest blood vessel — without major complications thanks to several preventive strategies, a study reported. To avoid complications from cold-induced hemolysis, or…
An 83-year-old woman with cold agglutinin disease (CAD) had knee surgery under local spinal anesthesia without any disease-related complications as a result of significant warming strategies to prevent her body temperature from getting too low, a study shows. During and after the surgery, the woman’s body temperature remained stable…
A woman in Taiwan likely developoed cold agglutinin disease (CAD) secondary to advanced diffuse large B-cell lymphoma (DLBCL), a type of fast-growing blood cancer that begins in immune B-cells, a study reports. This case adds to a growing, but still small, number of reports linking the two diseases. “We…
A woman with cold agglutinin disease (CAD) developed a rare type of kidney damage caused by the accumulation of faulty antibodies inside small blood vessels, a case study shows. This accumulation is also known as intracapillary deposits of monoclonal immunoglobulin M (IgM) antibodies. “To the best of our knowledge,…
A woman in Sri Lanka likely developed secondary cold agglutinin disease (CAD) that resulted from a rare type of “unusual and clinically aggressive” diffuse large B-cell lymphoma, a fast-growing blood cancer that formed in immune B-cells and involved the bone marrow, liver, and spleen. The case is the first…
The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale, a widely used questionnaire to assess fatigue, is reliable, valid, and responsive to changes in the severity of cold agglutinin disease (CAD), according to a study. The findings relied on CAD patients’ impressions of the FACIT-Fatigue scale and data from…
Annexon Biosciences’ new tablet formulation of its experimental therapy ANX1502 reduced key clinical and biomarker measures in the three cold agglutinin disease (CAD) patients so far enrolled in a proof-of-concept clinical trial. “In patients treated with the oral small molecule ANX1502, we are encouraged by the changes in…
An autologous stem cell transplant (ASCT) to treat lymphoma, a blood cancer, was safely performed in a man with severe cold agglutinin disease (CAD) who was dependent on blood transfusions, researchers in Canada have reported. Several strategies for a successful transplant were used to avoid potential complications from…
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