Warming strategies to prevent body temperature from dropping enabled a 42-year-old woman with cold agglutinin disease (CAD) to undergo a hysterectomy under general anesthesia without any disease-related complications, a study shows. “Comprehensive strategies — including measures to promote heat production, maintain core temperature, and prevent redistributive hypothermia — are…
A middle-aged woman in Iran with a history of Raynaud’s phenomenon was found to have cold agglutinin disease (CAD) after developing blue-tinged skin, known medically as acrocyanosis, and other severe symptoms, according to a case report highlighting the importance of early diagnosis and treatment in CAD. Raynaud’s…
A 79-year-old woman developed cold agglutinin disease (CAD) secondary to a rare, aggressive type of blood cancer called intravascular large B-cell lymphoma (IVLBCL), a case study reports. B-cell lymphomas are a form of blood cancer that affects B-cells, the type of white blood cell that produces antibodies, including those that…
Cold agglutinin disease (CAD) appears to be the most common type of autoimmune hemolytic anemia (AIHA) — a group of autoimmune diseases marked by attacks on red blood cells — that is triggered by COVID-19, according to a review of published studies. Patients developed AIHA about 13 days after…
Riliprubart (SAR445088), a potential successor to Enjaymo (sutimlimab-jome) as a cold agglutinin disease (CAD) treatment, may achieve therapeutic levels with every-three-month dosing at a fixed dose. That’s according to a study that used modeling tools to analyze available clinical trial data and propose an optimal dosing regimen for…
Nearly half of people without symptoms of cold agglutinin disease (CAD) who undergo a lung transplant test positive for cold agglutinins, the self-reactive antibodies that drive the rare autoimmune condition by targeting red blood cells at low temperatures. That’s according to new data from the first study of its kind…
A 12-year-old girl in Italy developed cold agglutinin disease (CAD) as a result of an infection with the Epstein-Barr virus (EBV), the virus that causes infectious mononucleosis, a case study reported. Treatment with the corticosteroid methylprednisolone and intravenous immunoglobin (IVIG) progressively led to complete resolution of her CAD symptoms.
An 83-year-old man with cold agglutinin disease (CAD) underwent surgery for an abdominal aortic aneurysm — a bulging in the lower part of the aorta, the body’s largest blood vessel — without major complications thanks to several preventive strategies, a study reported. To avoid complications from cold-induced hemolysis, or…
An 83-year-old woman with cold agglutinin disease (CAD) had knee surgery under local spinal anesthesia without any disease-related complications as a result of significant warming strategies to prevent her body temperature from getting too low, a study shows. During and after the surgery, the woman’s body temperature remained stable…
A woman in Taiwan likely developoed cold agglutinin disease (CAD) secondary to advanced diffuse large B-cell lymphoma (DLBCL), a type of fast-growing blood cancer that begins in immune B-cells, a study reports. This case adds to a growing, but still small, number of reports linking the two diseases. “We…
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