News

A woman in Sri Lanka likely developed secondary cold agglutinin disease (CAD) that resulted from a rare type of “unusual and clinically aggressive” diffuse large B-cell lymphoma, a fast-growing blood cancer that formed in immune B-cells and involved the bone marrow, liver, and spleen. The case is the first…

The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale, a widely used questionnaire to assess fatigue, is reliable, valid, and responsive to changes in the severity of cold agglutinin disease (CAD), according to a study. The findings relied on CAD patients’ impressions of the FACIT-Fatigue scale and data from…

Annexon Biosciences’ new tablet formulation of its experimental therapy ANX1502 reduced key clinical and biomarker measures in the three cold agglutinin disease (CAD) patients so far enrolled in a proof-of-concept clinical trial. “In patients treated with the oral small molecule ANX1502, we are encouraged by the changes in…

An autologous stem cell transplant (ASCT) to treat lymphoma, a blood cancer, was safely performed in a man with severe cold agglutinin disease (CAD) who was dependent on blood transfusions, researchers in Canada have reported. Several strategies for a successful transplant were used to avoid potential complications from…

Nearly half of children and teens with autoimmune hemolytic anemia (AIHA) — a group of disorders that includes cold agglutinin disease (CAD)  — have signs of erythrophagocytosis, or the removal of old and damaged red blood cells by immune cells, in blood samples, a small study shows. While erythrophagocytosis…

Few cases of cold agglutinin disease (CAD) secondary to systemic lupus erythematosus, or SLE, have been reported over the past seven decades, but all occurred in women, according to a study by two researchers in Colombia. In addition to describing two new cases of CAD secondary to SLE —…

Clinicians detected B-cell lymphoma, a type of blood cancer, in a 53-year-old man two years after he was diagnosed with cold agglutinin disease (CAD) marked by anemia, or low counts of red blood cells, but no symptoms, a case study indicates. All signs of lymphoma and CAD disappeared after…

Cold agglutinin disease (CAD) was the likely cause of blood clot formation during brain surgery in a 57-year-old man, despite measures to prevent his body temperature from getting too low, a case study in Turkey showed. Because the clot occurred at the site where two brain blood vessels were…

A boy in China was diagnosed with a rare case of cold agglutinin disease (CAD) associated with a Mycoplasma pneumoniae lung infection and a pulmonary embolism, which is a blood clot in the arteries that supply the lungs, according to a new case report. After treatment with antibiotics,…

A 50-year-old woman in the U.S. developed secondary cold agglutinin disease (CAD), a rare form of autoimmune anemia, as a complication of advanced breast cancer, a case study detailed. The researchers acknowledged that CAD “is rarely secondary to solid tumors,” as are typically seen in breast cancer. But they…