The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale, a widely used questionnaire to assess fatigue, is reliable, valid, and responsive to changes in the severity of cold agglutinin disease (CAD), according to a study. The findings relied on CAD patients’ impressions of the FACIT-Fatigue scale and data from…
Annexon Biosciences’ new tablet formulation of its experimental therapy ANX1502 reduced key clinical and biomarker measures in the three cold agglutinin disease (CAD) patients so far enrolled in a proof-of-concept clinical trial. “In patients treated with the oral small molecule ANX1502, we are encouraged by the changes in…
Nearly half of children and teens with autoimmune hemolytic anemia (AIHA) — a group of disorders that includes cold agglutinin disease (CAD) — have signs of erythrophagocytosis, or the removal of old and damaged red blood cells by immune cells, in blood samples, a small study shows. While erythrophagocytosis…
Clinicians detected B-cell lymphoma, a type of blood cancer, in a 53-year-old man two years after he was diagnosed with cold agglutinin disease (CAD) marked by anemia, or low counts of red blood cells, but no symptoms, a case study indicates. All signs of lymphoma and CAD disappeared after…
A boy in China was diagnosed with a rare case of cold agglutinin disease (CAD) associated with a Mycoplasma pneumoniae lung infection and a pulmonary embolism, which is a blood clot in the arteries that supply the lungs, according to a new case report. After treatment with antibiotics,…
Researchers said a case of cold agglutinin disease (CAD) in a 92-year-old man in Pakistan illustrates the challenges of CAD diagnosis and management in developing countries. The man’s experience highlights “the urgent need to improve healthcare infrastructure and enhance diagnostic capabilities while facilitating equitable access to essential CAD treatments…
A 50-year-old woman developed cold agglutinin disease (CAD) secondary to two different types of cancer within the thyroid gland, a study reported. The surgical removal of the thyroid gland successfully treated both the cancer and CAD. While CAD has been reported to occur secondary to blood cancers, it is…
Treatment with erythropoietin (EPO), a hormone that stimulates red blood cell production, safely increases hemoglobin levels in adults with cold agglutinin disease (CAD) and other autoimmune hemolytic anemias (AIHAs), according to a single-center study in Italy. Data show the treatment was effective in patients with abnormally low levels…
Diagnosis and treatment of cold agglutinin disease (CAD) secondary to a type of blood cancer was complicated by COVID-19 in a middle-aged man, a case study reports. The researchers identified specific mutations in immune cells that may explain the “treatment resistance and susceptibility to COVID-19,” they wrote in the…
Two approved blood cancer treatments, daratumumab and bortezomib, were each partially effective at reducing signs of cold agglutin disease (CAD) in two people with hard-to-treat cases of the autoimmune disorder, a study showed. These two therapies, alone or in combination, also were found to effectively treat five of six people with other…
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