A 44-year-old man with cold agglutinin disease (CAD) secondary to lymphoplasmacytic lymphoma, a type of blood cancer, recovered quickly after starting iptacopan, an oral therapy that targets the complement system, together with lymphoma treatment, a study showed. The complement cascade is a part of the immune system that contributes…
Cold agglutinin disease (CAD) secondary to Mycoplasma pneumoniae (M. pneumoniae) infection in adults is linked to severe illness, including a high risk of complications related to blood clots and intensive care admissions, according to a national study in France. Still, data showed that most patients recover within weeks with…
A teenage girl in the U.K. was treated after developing cold agglutinin disease (CAD) as a rare complication of systemic lupus erythematosus (SLE), the most common form of the autoimmune disease lupus. CAD is a type of autoimmune hemolytic anemia (AIHA) that’s marked by immune attacks against red…
Treatment with rituximab — commonly used off-label for cold agglutinin disease (CAD) — was found to improve biomarkers of red blood cell destruction in people with CAD, but these benefits were often short-term and reversed within a few months, according to a real-world study in the U.S. The study also…
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