Laboratories testing for cold agglutinins — the self-reactive antibodies causing cold agglutinin disease (CAD) — need to use standard protocols to provide accurate results, compare results between studies, and guide treatment, researchers said. “International standardization of CA [cold agglutinin] testing for diagnostic use is essential,” the researchers wrote.
A woman with cold agglutinin disease (CAD) developed an aggressive B-cell lymphoma after having only a brief response to Enjaymo (sutimlimab), according to a case report. Researchers said the “case highlights the importance of reassessing underlying conditions through [a bone marrow biopsy] in cases where [Enjaymo] treatment is…
An 83-year-old man with cold agglutinin disease (CAD) underwent surgery for an abdominal aortic aneurysm — a bulging in the lower part of the aorta, the body’s largest blood vessel — without major complications thanks to several preventive strategies, a study reported. To avoid complications from cold-induced hemolysis, or…
A woman in Taiwan likely developoed cold agglutinin disease (CAD) secondary to advanced diffuse large B-cell lymphoma (DLBCL), a type of fast-growing blood cancer that begins in immune B-cells, a study reports. This case adds to a growing, but still small, number of reports linking the two diseases. “We…
A woman with cold agglutinin disease (CAD) developed a rare type of kidney damage caused by the accumulation of faulty antibodies inside small blood vessels, a case study shows. This accumulation is also known as intracapillary deposits of monoclonal immunoglobulin M (IgM) antibodies. “To the best of our knowledge,…
A woman in Sri Lanka likely developed secondary cold agglutinin disease (CAD) that resulted from a rare type of “unusual and clinically aggressive” diffuse large B-cell lymphoma, a fast-growing blood cancer that formed in immune B-cells and involved the bone marrow, liver, and spleen. The case is the first…
An autologous stem cell transplant (ASCT) to treat lymphoma, a blood cancer, was safely performed in a man with severe cold agglutinin disease (CAD) who was dependent on blood transfusions, researchers in Canada have reported. Several strategies for a successful transplant were used to avoid potential complications from…
Few cases of cold agglutinin disease (CAD) secondary to systemic lupus erythematosus, or SLE, have been reported over the past seven decades, but all occurred in women, according to a study by two researchers in Colombia. In addition to describing two new cases of CAD secondary to SLE —…
A Japanese man with severe anemia — a condition marked by too few red blood cells in the body — following a case of COVID-19 tested positive for cold agglutinins and cryoglobulins, two types of antibodies that become reactive in the cold, according to a new report. Cold agglutinins are…
Warming and an extra dose of corticosteroid medication were part of multiple strategies doctors used to allow for a safe Cesarean section (c-section), without complications, in a pregnant woman with cold agglutinin disease (CAD), according to a case report. The woman was kept warm right during her hospital stay,…
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