An underlying disorder involving abnormal cell growth turned out to be at the root of cold agglutinin disease (CAD) in a 78-year-old woman. The woman had monoclonal B-cell lymphocytosis (MBL), a condition that occurs when a group of identical white blood cells, in this case B-cells, grows abnormally, a…
A new tablet formulation of Annexon Biosciences’ experimental therapy ANX1502 resulted in therapy levels in the blood that surpassed those expected to be effective in fasting participants with cold agglutinin disease (CAD). These results from a proof-of-concept study reflect a promising pharmacokinetic profile, which describes how the medication…
A dental infection triggered an attack of red blood cell destruction, or hemolysis, in a man in his 40s with cold agglutinin disease (CAD), according to a case report from Japan that, researchers say, highlights the need for CAD patients to maintain good oral hygiene. Previous studies have reported…
Thrombotic events (TE), or the blockage of blood flow due to blood clots, are relatively common among adults with cold agglutinin disease (CAD) and other forms of autoimmune hemolytic anemia (AIHA), according to a study in France. Researchers also found that experiencing five or more hemolytic attacks marked by…
Up to about 1 person in 100,000 in the U.S. is estimated to be diagnosed with primary cold agglutinin disease (CAD) each year and up to 3 in 10,000 people are living with the disease, a study that analyzed 2016-2023 data from national claim databases suggests. Primary CAD…
A 76-year-old woman with cold agglutinin disease (CAD) underwent an emergency upper endoscopy, a procedure to look at the upper gastrointestinal tract, without any disease-related complications, thanks to warming strategies that prevented her body temperature from getting too low, a study shows. Such strategies included raising the temperature of…
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